What is a GUID?
GUID (aka UUID) is an acronym for 'Globally Unique Identifier' (or 'Universally Unique Identifier'). It is a 128-bit integer number used to identify resources. The term GUID is generally used by developers working with Microsoft technologies, while UUID is used everywhere else.
How unique is a GUID?
128-bits is big enough and the generation algorithm is unique enough that if 1,000,000,000 GUIDs per second were generated for 1 year the probability of a duplicate would be only 50%. Or if every human on Earth generated 600,000,000 GUIDs there would only be a 50% probability of a duplicate.